The function computes predicted values, corresponding standard errors, confidence intervals, and (approximate) prediction intervals for objects of class "rma".

# S3 method for rma
predict(object, newmods, intercept, tau2.levels, gamma2.levels,
addx=FALSE, level, digits, transf, targs, vcov=FALSE, ...)

## Arguments

object an object of class "rma". optional vector or matrix to specify the values of the moderator values for which the predicted values should be calculated. See ‘Details’. logical to specify whether the intercept should be included when calculating the predicted values for newmods. If unspecified, the intercept is automatically added when the original model also included an intercept. vector to specify the levels of the inner factor when computing prediction intervals. Only relevant for models of class "rma.mv" (see rma.mv) and when the model includes more than a single $$\tau^2$$ value. See ‘Details’. vector to specify the levels of the inner factor when computing prediction intervals. Only relevant for models of class "rma.mv" (see rma.mv) and when the model includes more than a single $$\gamma^2$$ value. See ‘Details’. logical to specify whether the values of the moderator variables should be added to the returned object. See ‘Examples’. numeric value between 0 and 100 to specify the confidence and prediction interval level (if unspecified, the default is to take the value from the object). integer to specify the number of decimal places to which the printed results should be rounded (if unspecified, the default is to take the value from the object). optional argument to specify the name of a function that should be used to transform the predicted values and interval bounds (e.g., transf=exp; see also transf). If unspecified, no transformation is used. optional arguments needed by the function specified under transf. logical to specify whether the variance-covariance matrix of the predicted values should also be returned (the default is FALSE). other arguments.

## Details

For a fixed-effects model, predict(object) returns the estimated (average) outcome in the set of studies included in the meta-analysis. This is the same as the estimated intercept in the fixed-effects model (i.e., $$\hat{\theta}$$).

For a random-effects model, predict(object) returns the estimated (average) outcome in the hypothetical population of studies from which the set of studies included in the meta-analysis are assumed to be a random selection. This is the same as the estimated intercept in the random-effects model (i.e., $$\hat{\mu}$$).

For models including one or more moderators, predict(object) returns the estimated (average) outcomes for values of the moderator(s) equal to those of the $$k$$ studies included in the meta-analysis (i.e., the fitted values for the $$k$$ studies ).

For models including $$p'$$ moderator variables, new moderator values for $$k_{new}$$ new studies can be specified by setting newmods equal to an $$k_{new} \times p'$$ matrix with the corresponding new moderator values. If the original model includes an intercept, then it should not be explicitly specified under newmods, as it will be added by default (unless one sets intercept=FALSE). Also, any factors in the original model get turned into the appropriate contrast variables within the rma function, so that newmods should actually include the values for the contrast variables. Examples are shown below.

For random/mixed-effects models, an approximate prediction interval is also calculated (Riley et al., 2011). The interval estimates where level % of the true effect sizes or outcomes fall in the hypothetical population of studies. Note that this interval is calculated under the assumption that the value of $$\tau^2$$ is known (and not estimated). A method for calculating a prediction interval that accounts for the uncertainty in the estimate of $$\tau^2$$ may be implemented in the future.

For random-effects models that were fitted with the rma.mv function, the model may actually include multiple $$\tau^2$$ values (i.e., when the random argument includes an ‘~ inner | outer’ term and struct="HCS", struct="DIAG", struct="HAR", or struct="UN"). In that case, the function will provide prediction intervals for each level of the inner factor (since the prediction intervals differ depending on the $$\tau^2$$ value). Alternatively, one can use the tau2.levels argument to specify for which level(s) the prediction interval should be provided. If the model includes a second ‘~ inner | outer’ term with multiple $$\gamma^2$$ values, prediction intervals for each combination of levels of the inner factors will be provided. Alternatively, one can use the tau2.levels and gamma2.levels arguments to specify for which level combination(s) the prediction interval should be provided.

When using the newmods argument for mixed-effects models that were fitted with the rma.mv function, if the model includes multiple $$\tau^2$$ (and multiple $$\gamma^2$$) values, then one must use the tau2.levels (and gamma2.levels) argument to specify the levels of the inner factor(s) (i.e., a vector of length $$k_{new}$$) to obtain the appropriate prediction interval(s).

## Value

An object of class "list.rma". The object is a list containing the following components:

pred

predicted value(s).

se

corresponding standard error(s).

ci.lb

lower bound of the confidence interval(s).

ci.ub

upper bound of the confidence interval(s).

pi.lb

lower bound of the prediction interval(s) (only for random/mixed-effects models).

pi.ub

upper bound of the prediction interval(s) (only for random/mixed-effects models).

tau2.level

the level(s) of the inner factor (only for models of class "rma.mv" with multiple $$\tau^2$$ values).

gamma2.level

the level(s) of the inner factor (only for models of class "rma.mv" with multiple $$\gamma^2$$ values).

X

the moderator value(s) used to calculate the predicted values (only when addx=TRUE).

...

If vcov=TRUE, then the returned object is a list with the first element equal to the one as described above and the second element equal to the variance-covariance matrix of the predicted values. The "list.rma" object is formatted and printed with print.list.rma.

## Note

Confidence and prediction intervals are calculated based on the critical values from a standard normal distribution (i.e., $$\pm 1.96$$ for level=95). When the model was fitted with the Knapp and Hartung (2003) method (i.e., test="knha" in the rma.uni function) or with test="t" in the rma.glmm and rma.mv functions, then a t-distribution with $$k-p$$ degrees of freedom is used.

For random-effects models of the type that can be fitted with the rma.uni function, note that this differs slightly from Riley et al. (2001), who suggest to use a t-distribution with $$k-2$$ degrees of freedom for constructing the prediction interval. Neither a normal, nor a t-distribution with $$k-1$$ or $$k-2$$ degrees of freedom is correct; all of these are approximations. The computations are done in the way described above, so that the prediction interval is identical to the confidence interval when $$\hat{\tau}^2 = 0$$, which could be argued is the logical thing that should happen. If the prediction interval should be computed exactly as described by Riley et al. (2001), then one can use argument pi.type="riley".

The predicted values are based only on the fixed effects of the model. Best linear unbiased predictions (BLUPs) that combine the fitted values based on the fixed effects and the estimated contributions of the random effects can be obtained with blup.rma.uni (currently only for objects of class "rma.uni").

When using the transf option, the transformation is applied to the predicted values and the corresponding interval bounds. The standard errors are omitted from the printed output. Also, vcov=TRUE is ignored when using the transf option.

## Author

Wolfgang Viechtbauer wvb@metafor-project.org http://www.metafor-project.org

## References

Hedges, L. V., & Olkin, I. (1985). Statistical methods for meta-analysis. San Diego, CA: Academic Press.

Riley, R. D., Higgins, J. P. T., & Deeks, J. J. (2011). Interpretation of random effects meta-analyses. British Medical Journal, 342, d549. https://doi.org/10.1136/bmj.d549

Viechtbauer, W. (2010). Conducting meta-analyses in R with the metafor package. Journal of Statistical Software, 36(3), 1--48. https://doi.org/10.18637/jss.v036.i03

fitted.rma, blup.rma.uni

## Examples

### meta-analysis of the log risk ratios using a random-effects model
res <- rma(measure="RR", ai=tpos, bi=tneg, ci=cpos, di=cneg, data=dat.bcg)

### average risk ratio with 95% CI
predict(res, transf=exp)
#>
#>    pred  ci.lb  ci.ub  pi.lb  pi.ub
#>  0.4894 0.3441 0.6962 0.1546 1.5490
#>
### mixed-effects model with absolute latitude as a moderator
res <- rma(measure="RR", ai=tpos, bi=tneg, ci=cpos, di=cneg, mods = ~ ablat,
data=dat.bcg)

### predicted average risk ratios for given absolute latitude values
#>
#>      pred  ci.lb  ci.ub  pi.lb  pi.ub X.intrcpt X.ablat
#> 1  0.3574 0.2714 0.4705 0.1947 0.6560         1      44
#> 2  0.2595 0.1749 0.3848 0.1328 0.5070         1      55
#> 3  0.3788 0.2927 0.4901 0.2079 0.6900         1      42
#> 4  0.2831 0.1977 0.4054 0.1478 0.5422         1      52
#> 5  0.8809 0.6321 1.2276 0.4667 1.6625         1      13
#> 6  0.3574 0.2714 0.4705 0.1947 0.6560         1      44
#> 7  0.7397 0.5639 0.9704 0.4036 1.3557         1      19
#> 8  0.8809 0.6321 1.2276 0.4667 1.6625         1      13
#> 9  0.5861 0.4716 0.7284 0.3270 1.0505         1      27
#> 10 0.3788 0.2927 0.4901 0.2079 0.6900         1      42
#> 11 0.7616 0.5752 1.0083 0.4138 1.4016         1      18
#> 12 0.4922 0.3989 0.6073 0.2753 0.8799         1      33
#> 13 0.4922 0.3989 0.6073 0.2753 0.8799         1      33
#>
### predicted average risk ratios for 10-60 degrees absolute latitude
predict(res, newmods=c(10, 20, 30, 40, 50, 60), transf=exp)
#>
#>     pred  ci.lb  ci.ub  pi.lb  pi.ub
#> 1 0.9612 0.6668 1.3857 0.5000 1.8478
#> 2 0.7185 0.5526 0.9343 0.3936 1.3117
#> 3 0.5371 0.4355 0.6623 0.3005 0.9600
#> 4 0.4015 0.3151 0.5115 0.2218 0.7266
#> 5 0.3001 0.2144 0.4201 0.1586 0.5678
#> 6 0.2243 0.1423 0.3538 0.1105 0.4552
#>
### mixed-effects model with two moderators (absolute latitude and publication year)
res <- rma(measure="RR", ai=tpos, bi=tneg, ci=cpos, di=cneg,
mods = ~ ablat + year, data=dat.bcg)

### predicted average risk ratios for 10 and 60 degrees latitude in 1950 and 1980
#>
#>     pred  ci.lb  ci.ub  pi.lb  pi.ub X.intrcpt X.ablat X.year
#> 1 0.8995 0.3689 2.1933 0.2981 2.7146         1      10   1950
#> 2 0.2217 0.1278 0.3847 0.0944 0.5208         1      60   1950
#> 3 0.9525 0.6199 1.4637 0.4361 2.0802         1      10   1980
#> 4 0.2348 0.1005 0.5481 0.0805 0.6843         1      60   1980
#>
### mixed-effects model with two moderators (one of which is a factor)
res <- rma(measure="RR", ai=tpos, bi=tneg, ci=cpos, di=cneg,
mods = ~ ablat + factor(alloc), data=dat.bcg)

### examine how the factor was actually coded for the studies in the dataset
#>
#>       pred     se   ci.lb   ci.ub   pi.lb   pi.ub X.intrcpt X.ablat
#> 1  -1.1744 0.2137 -1.5932 -0.7557 -2.0293 -0.3196         1      44
#> 2  -1.4745 0.2742 -2.0119 -0.9370 -2.3933 -0.5556         1      55
#> 3  -1.1199 0.2061 -1.5238 -0.7159 -1.9676 -0.2722         1      42
#> 4  -1.3926 0.2552 -1.8928 -0.8925 -2.2902 -0.4951         1      52
#> 5  -0.0614 0.3336 -0.7152  0.5924 -1.0528  0.9300         1      13
#> 6  -0.9069 0.3176 -1.5295 -0.2844 -1.8780  0.0642         1      44
#> 7  -0.4925 0.2338 -0.9508 -0.0343 -1.3674  0.3823         1      19
#> 8  -0.3289 0.2694 -0.8568  0.1991 -1.2422  0.5845         1      13
#> 9  -0.7107 0.2007 -1.1040 -0.3175 -1.5534  0.1320         1      27
#> 10 -0.7939 0.2667 -1.3166 -0.2712 -1.7042  0.1164         1      42
#> 11 -0.1393 0.2654 -0.6594  0.3808 -1.0481  0.7695         1      18
#> 12 -0.5484 0.2438 -1.0263 -0.0706 -1.4337  0.3369         1      33
#> 13 -0.5484 0.2438 -1.0263 -0.0706 -1.4337  0.3369         1      33
#>    X.factor.alloc.random X.factor.alloc.systematic
#> 1                      1                         0
#> 2                      1                         0
#> 3                      1                         0
#> 4                      1                         0
#> 5                      0                         0
#> 6                      0                         0
#> 7                      1                         0
#> 8                      1                         0
#> 9                      1                         0
#> 10                     0                         1
#> 11                     0                         1
#> 12                     0                         1
#> 13                     0                         1
#>
### predictd average risk ratios at 30 degrees for the three factor levels
### note: the contrast (dummy) variables need to specified explicitly here
predict(res, newmods=c(30, 0, 0), addx=TRUE)   # for alternate  allocation
#>
#>     pred     se   ci.lb  ci.ub   pi.lb  pi.ub X.intrcpt X.ablat
#>  -0.5251 0.2923 -1.0980 0.0478 -1.4651 0.4149         1      30
#>  X.factor.alloc.random X.factor.alloc.systematic
#>                      0                         0
#> predict(res, newmods=c(30, 1, 0), addx=TRUE)   # for random     allocation
#>
#>     pred     se   ci.lb   ci.ub   pi.lb  pi.ub X.intrcpt X.ablat
#>  -0.7926 0.1941 -1.1729 -0.4122 -1.6293 0.0442         1      30
#>  X.factor.alloc.random X.factor.alloc.systematic
#>                      1                         0
#> predict(res, newmods=c(30, 0, 1), addx=TRUE)   # for systematic allocation
#>
#>     pred     se   ci.lb  ci.ub   pi.lb  pi.ub X.intrcpt X.ablat
#>  -0.4666 0.2420 -0.9410 0.0078 -1.3501 0.4168         1      30
#>  X.factor.alloc.random X.factor.alloc.systematic
#>                      0                         1
#>
### can also use named vector with arbitrary order and abbreviated variable names
predict(res, newmods=c(sys=0, ran=0, abl=30))
#>
#>     pred     se   ci.lb  ci.ub   pi.lb  pi.ub
#>  -0.5251 0.2923 -1.0980 0.0478 -1.4651 0.4149
#> predict(res, newmods=c(sys=0, ran=1, abl=30))
#>
#>     pred     se   ci.lb   ci.ub   pi.lb  pi.ub
#>  -0.7926 0.1941 -1.1729 -0.4122 -1.6293 0.0442
#> predict(res, newmods=c(sys=1, ran=0, abl=30))
#>
#>     pred     se   ci.lb  ci.ub   pi.lb  pi.ub
#>  -0.4666 0.2420 -0.9410 0.0078 -1.3501 0.4168
#>