Forest Plots (Default Method) — forest.default • metafor

Function to create forest plots for a given set of data.

# S3 method for default
forest(x, vi, sei, ci.lb, ci.ub,
       annotate=TRUE, showweights=FALSE, header=FALSE,
       xlim, alim, olim, ylim, at, steps=5,
       level=95, refline=0, digits=2L, width,
       xlab, slab, ilab, ilab.xpos, ilab.pos,
       order, subset, transf, atransf, targs, rows,
       efac=1, pch, psize, plim=c(0.5,1.5), col,
       shade, colshade, lty, fonts, cex, cex.lab, cex.axis, ...)

Arguments

x: vector of length \(k\) with the observed effect sizes or outcomes.
vi: vector of length \(k\) with the corresponding sampling variances.
sei: vector of length \(k\) with the corresponding standard errors (note: only one of the two, vi or sei, needs to be specified).
ci.lb: vector of length \(k\) with the corresponding lower confidence interval bounds. Not needed if vi or sei is specified. See ‘Details’.
ci.ub: vector of length \(k\) with the corresponding upper confidence interval bounds. Not needed if vi or sei is specified. See ‘Details’.
annotate: logical to specify whether annotations should be added to the plot (the default is TRUE).
showweights: logical to specify whether the annotations should also include the inverse variance weights (the default is FALSE).
header: logical to specify whether column headings should be added to the plot (the default is FALSE). Can also be a character vector to specify the left and right headings (or only the left one).
xlim: horizontal limits of the plot region. If unspecified, the function sets the horizontal plot limits to some sensible values.
alim: the x-axis limits. If unspecified, the function sets the x-axis limits to some sensible values.
olim: optional argument to specify observation/outcome limits. If unspecified, no limits are used.
ylim: the y-axis limits of the plot. If unspecified, the function sets the y-axis limits to some sensible values. Can also be a single value to set the lower bound (while the upper bound is still set automatically).
at: position of the x-axis tick marks and corresponding labels. If unspecified, the function sets the tick mark positions/labels to some sensible values.
steps: the number of tick marks for the x-axis (the default is 5). Ignored when the positions are specified via the at argument.
level: numeric value between 0 and 100 to specify the confidence interval level (the default is 95; see here for details).
refline: numeric value to specify the location of the vertical ‘reference’ line (the default is 0). The line can be suppressed by setting this argument to NA.
digits: integer to specify the number of decimal places to which the tick mark labels of the x-axis and the annotations should be rounded (the default is 2L). Can also be a vector of two integers, the first to specify the number of decimal places for the annotations, the second for the x-axis labels (when showweights=TRUE, can also specify a third value for the weights). When specifying an integer (e.g., 2L), trailing zeros after the decimal mark are dropped for the x-axis labels. When specifying a numeric value (e.g., 2), trailing zeros are retained.
width: optional integer to manually adjust the width of the columns for the annotations (either a single integer or a vector of the same length as the number of annotation columns).
xlab: title for the x-axis. If unspecified, the function sets an appropriate axis title. Can also be a vector of three/two values (to also/only add labels at the end points of the x-axis limits).
slab: optional vector with labels for the \(k\) studies. If unspecified, the function tries to extract study labels from x and otherwise simple labels are created within the function. To suppress labels, set this argument to NA.
ilab: optional vector, matrix, or data frame providing additional information about the studies that should be added to the plot.
ilab.xpos: numeric vector to specify the horizontal position(s) of the variable(s) given via ilab.
ilab.pos: integer(s) (either 1, 2, 3, or 4) to specify the alignment of the vector(s) given via ilab (2 means right, 4 mean left aligned). If unspecified, the default is to center the labels.
order: optional character string to specify how the studies should be ordered. Can also be a variable based on which the studies will be ordered. See ‘Details’.
subset: optional (logical or numeric) vector to specify the subset of studies that should be included in the plot.
transf: optional argument to specify a function to transform the observed outcomes and corresponding confidence interval bounds (e.g., transf=exp; see also transf). If unspecified, no transformation is used.
atransf: optional argument to specify a function to transform the x-axis labels and annotations (e.g., atransf=exp; see also transf). If unspecified, no transformation is used.
targs: optional arguments needed by the function specified via transf or atransf.
rows: optional vector to specify the rows (or more generally, the horizontal positions) for plotting the outcomes. Can also be a single value to specify the row (horizontal position) of the first outcome (the remaining outcomes are then plotted below this starting row).
efac: vertical expansion factor for confidence interval limits and arrows. The default value of 1 should usually work okay. Can also be a vector of two numbers, the first for CI limits, the second for arrows.
pch: plotting symbol to use for the observed outcomes. By default, a filled square is used. See points for other options. Can also be a vector of values.
psize: optional numeric value to specify the point sizes for the observed outcomes. If unspecified, the point sizes are a function of the precision of the estimates. Can also be a vector of values.
plim: numeric vector of length 2 to scale the point sizes (ignored when psize is specified). See ‘Details’.
col: optional character string to specify the color of the observed outcomes. Can also be a vector.
shade: optional character string or a (logical or numeric) vector for shading rows of the plot. See ‘Details’.
colshade: optional argument to specify the color for the shading.
lty: optional character string to specify the line type for the confidence intervals. If unspecified, the function sets this to "solid" by default.
fonts: optional character string to specify the font for the study labels, annotations, and the extra information (if specified via ilab). If unspecified, the default font is used.
cex: optional character and symbol expansion factor. If unspecified, the function sets this to a sensible value.
cex.lab: optional expansion factor for the x-axis title. If unspecified, the function sets this to a sensible value.
cex.axis: optional expansion factor for the x-axis labels. If unspecified, the function sets this to a sensible value.
...: other arguments.

Details

The plot shows the observed effect sizes or outcomes with corresponding confidence intervals. To use the function, one should specify the observed outcomes (via the x argument) together with the corresponding sampling variances (via the vi argument) or with the corresponding standard errors (via the sei argument). Alternatively, one can specify the observed outcomes together with the corresponding confidence interval bounds (via the ci.lb and ci.ub arguments).

With the transf argument, the observed outcomes and corresponding confidence interval bounds can be transformed with some suitable function. For example, when plotting log odds ratios, then one could use transf=exp to obtain a forest plot showing the odds ratios. Alternatively, one can use the atransf argument to transform the x-axis labels and annotations (e.g., atransf=exp). See also transf for some other useful transformation functions in the context of a meta-analysis. The examples below illustrate the use of these arguments.

By default, the studies are ordered from top to bottom (i.e., the first study in the dataset will be placed in row \(k\), the second study in row \(k-1\), and so on, until the last study, which is placed in the first row). The studies can be reordered with the order argument:

order="obs": the studies are ordered by the observed outcomes,
order="prec": the studies are ordered by their sampling variances.

Alternatively, it is also possible to set order equal to a variable based on which the studies will be ordered (see ‘Examples’).

Additional columns with information about the studies can be added to the plot via the ilab argument. This can either be a single variable or an entire matrix / data frame (with as many rows as there are studies in the forest plot). The ilab.xpos argument can then also be used to specify the horizontal position of the variables specified via ilab.

Summary estimates can be added to the plot with the addpoly function. See the documentation for that function for examples.

By default (i.e., when psize is not specified), the point sizes are a function of the precision (i.e., inverse standard errors) of the outcomes. This way, more precise estimates are visually more prominent in the plot. By making the point sizes a function of the inverse standard errors of the estimates, their areas are proportional to the inverse sampling variances, which corresponds to the weights they would receive in an equal-effects model. However, the point sizes are rescaled so that the smallest point size is plim[1] and the largest point size is plim[2]. As a result, their relative sizes (i.e., areas) no longer exactly correspond to their relative weights in such a model. If exactly relative point sizes are desired, one can set plim[2] to NA, in which case the points are rescaled so that the smallest point size corresponds to plim[1] and all other points are scaled accordingly. As a result, the largest point may be very large. Alternatively, one can set plim[1] to NA, in which case the points are rescaled so that the largest point size corresponds to plim[2] and all other points are scaled accordingly. As a result, the smallest point may be very small and essentially indistinguishable from the confidence interval line. To avoid the latter, one can also set plim[3], which enforces a minimal point size.

With the shade argument, one can shade rows of the plot. The argument can be set to one of the following character strings: "zebra" (same as shade=TRUE) or "zebra2" to use zebra-style shading (starting either at the first or second study) or to "all" in which case all rows are shaded. Alternatively, the argument can be set to a logical or numeric vector to specify which rows should be shaded. The colshade argument can be used to set the color of shaded rows.

Note

The function sets some sensible values for the optional arguments, but it may be necessary to adjust these in certain circumstances.

The function actually returns some information about the chosen values invisibly. Printing this information is useful as a starting point to make adjustments to the plot.

If the number of studies is quite large, the labels, annotations, and symbols may become quite small and impossible to read. Stretching the plot window vertically may then provide a more readable figure (one should call the function again after adjusting the window size, so that the label/symbol sizes can be properly adjusted). Also, the cex, cex.lab, and cex.axis arguments are then useful to adjust the symbol and text sizes.

If the outcome measure used for creating the plot is bounded (e.g., correlations are bounded between -1 and +1, proportions are bounded between 0 and 1), one can use the olim argument to enforce those limits (the observed outcomes and confidence intervals cannot exceed those bounds then).

The lty argument can also be a vector of two elements, the first for specifying the line type of the individual CIs ("solid" by default), the second for the line type of the horizontal line that is automatically added to the plot ("solid" by default; set to "blank" to remove it).

Additional Optional Arguments

There are some additional optional arguments that can be passed to the function via ... (hence, they cannot be abbreviated):

top: single numeric value to specify the amount of space (in terms of number of rows) to leave empty at the top of the plot (e.g., for adding headers). The default is 3.
annosym: vector of length 3 to select the left bracket, separation, and right bracket symbols for the annotations. The default is c(" [", ", ", "]"). Can also include a 4th element to adjust the look of the minus symbol, for example to use a proper minus sign (−) instead of a hyphen-minus (-). Can also include a 5th element that should be a space-like symbol (e.g., an ‘en space’) that is used in place of numbers (only relevant when trying to line up numbers exactly). For example, annosym=c(" [", ", ", "]", "\u2212", "\u2002") would use a proper minus sign and an ‘en space’ for the annotations.
tabfig: single numeric value (either a 1, 2, or 3) to set annosym automatically to a vector that will exactly align the numbers in the annotations when using a font that provides ‘tabular figures’. Value 1 corresponds to using "\u2212" (a minus) and "\u2002" (an ‘en space’) in annoyym as shown above. Value 2 corresponds to "\u2013" (an ‘en dash’) and "\u2002" (an ‘en space’). Value 3 corresponds to "\u2212" (a minus) and "\u2007" (a ‘figure space’). The appropriate value for this argument depends on the font used. For example, for fonts Calibri and Carlito, 1 or 2 should work; for fonts Source Sans 3 and Palatino Linotype, 1, 2, and 3 should all work; for Computer/Latin Modern and Segoe UI, 2 should work; for Lato, Roboto, and Open Sans (and maybe Arial), 3 should work. Other fonts may work as well, but this is untested.
textpos: numeric vector of length 2 to specify the placement of the study labels and the annotations. The default is to use the horizontal limits of the plot region, i.e., the study labels to the right of xlim[1] and the annotations to the left of xlim[2].
rowadj: numeric vector of length 3 to vertically adjust the position of the study labels, the annotations, and the extra information (if specified via ilab). This is useful for fine-tuning the position of text added with different positional alignments (i.e., argument pos in the text function).

Author

Wolfgang Viechtbauer wvb@metafor-project.org https://www.metafor-project.org

References

Lewis, S., & Clarke, M. (2001). Forest plots: Trying to see the wood and the trees. British Medical Journal, 322(7300), 1479–1480. https://doi.org/10.1136/bmj.322.7300.1479

Viechtbauer, W. (2010). Conducting meta-analyses in R with the metafor package. Journal of Statistical Software, 36(3), 1–48. https://doi.org/10.18637/jss.v036.i03

Examples

### calculate log risk ratios and corresponding sampling variances
dat <- escalc(measure="RR", ai=tpos, bi=tneg, ci=cpos, di=cneg,
              data=dat.bcg, slab=paste(author, year, sep=", "))

### default forest plot of the observed log risk ratios
forest(dat$yi, dat$vi, header=TRUE)

### the with() function can be used to avoid having to retype dat$... over and over
with(dat, forest(yi, vi, header=TRUE))


### forest plot of the observed risk ratios (transform outcomes)
with(dat, forest(yi, vi, transf=exp, alim=c(0,2), steps=5,
                 xlim=c(-2.5,4), refline=1, cex=0.9, header=TRUE, top=2))


### forest plot of the observed risk ratios (transformed x-axis)
with(dat, forest(yi, vi, atransf=exp, at=log(c(0.05,0.25,1,4,20)),
                 xlim=c(-10,8), cex=0.9, header=TRUE, top=2))


### forest plot of the observed risk ratios with studies ordered by the RRs
with(dat, forest(yi, vi, atransf=exp, at=log(c(0.05,0.25,1,4,20)),
                 xlim=c(-10,8), cex=0.9, header=TRUE, top=2, order="obs"))


### forest plot of the observed risk ratios with studies ordered by absolute latitude
with(dat, forest(yi, vi, atransf=exp, at=log(c(0.05,0.25,1,4,20)),
                 xlim=c(-10,8), cex=0.9, header=TRUE, top=2, order=ablat))


### see also examples for the forest.rma function