Trials on Non-Steroidal Anti-Inflammatory Drugs in Acute Pain

Results from 37 trials evaluating non-steroidal anti-inflammatory drugs (NSAIDS) in patients with acute pain.

dat.moore1998

Format

The data frame contains the following columns:

id	integer	study ID
author	character	first author
year	integer	publication year
Ee	integer	number of treatment successes (NSAIDS group)
Ne	integer	number of patients (NSAIDS group)
Ec	integer	number of treatment successes (control group)
Nc	integer	number of patients (control group)
nonenglish	integer	non-English publication
medline	integer	listed in Medline
grey	integer	grey literature
samecont	integer	same control group
journal	character	journal

Details

Moore et al. (1998) conducted a systematic review of 37 randomized placebo-controlled trials on the effectiveness and safety of topical non-steroidal anti-inflammatory drugs (NSAIDS) in acute pain. The main outcome was treatment success, defined as a reduction in pain of at least 50%.

This data set is used as an example in Schwarzer et al. (2015).

Source

Moore, R. A., Tramèr, M. R., Carroll, D., Wiffen, P. J., & McQuay, H. J. (1998). Quantitive systematic review of topically applied non-steroidal anti-inflammatory drugs. British Medical Journal, 316(7128), 333–338. https://doi.org/10.1136/bmj.316.7128.333

References

Schwarzer, G., Carpenter, J. R., & Rücker, G. (2015). Meta-analysis with R. Cham, Switzerland: Springer.

Author

Guido Schwarzer, guido.schwarzer@uniklinik-freiburg.de, https://github.com/guido-s/

Concepts

medicine, odds ratios, publication bias

Examples

### Show first five studies
head(dat.moore1998, 5)
#>   id     author year Ee  Ne Ec  Nc nonenglish medline grey samecont
#> 1  1 Airaksinen 1993 24  29 14  27          0       1    0        0
#> 2  2   Akermark 1990 10  23  3  24          0       1    0        0
#> 3  3       Aoki 1984 56  84 33  84          1       0    0        1
#> 4  4       Aoki 1984 41  84 33  84          1       0    0        1
#> 5  5    Auclair 1989 69 123 54 116          0       0    0        0
#>                                    journal
#> 1 Int J of Clin Pharm Therapy & Toxicology
#> 2                 Int J of Sports Medicine
#> 3     Japanese Pharmacology & Therapeutics
#> 4     Japanese Pharmacology & Therapeutics
#> 5                            Curr Ther Res

### Load meta package
suppressPackageStartupMessages(library(meta))

### Conduct meta-analysis
m <- metabin(Ee, Ne, Ec, Nc, data = dat.moore1998,
  sm = "OR", studlab = id,
  label.e = "NSAIDS", label.c = "Placebo")

### Funnel plot
fun <- funnel(m, type = "contour",
  random = FALSE, pch = 16)
legend(0.25, 1.25, bty = "n",
  legend = fun$text.contour, fill = fun$col.contour)